Fisetin and the Senolytic Problem: Why Mouse Data Has Not Translated
Fisetin senolytic research explained: what the mouse studies found, why human trials lag, bioavailability problems, and what is still unknown.
NAC (N-Acetylcysteine): Strong Evidence in Some Places, Thin in Others
N-acetylcysteine evidence reviewed: proven clinical uses, glutathione claims, psychiatric trial data, and where research does not support the hype.
Berberine: What the Randomized Trials Show, and the Interactions Nobody Mentions
Berberine reviewed against randomized human trials: glucose and lipid effects, bioavailability limits, and serious CYP450 drug interactions.
Metformin for Longevity: Separating the Trial Data From the Hype
What metformin research actually shows on aging, the exercise-blunting finding, B12 depletion, and why TAME still has not answered the question.
Creatine Monohydrate: What 30 Years of Human Trials Actually Show
Creatine monohydrate evidence reviewed: strength gains, cognition, kidney safety myths, dosing from trials, and what remains unproven.
NAD+ Supplements: Do They Work for Biohackers?
The biohacking and longevity community has been buzzing about NAD+ supplements, with celebrities and performance optimization enthusiasts embracing these compounds as potential anti-aging and energy-boosting solutions. According to a recent New York Post report, NAD+ supplementation has become a staple among those seeking to optimize their health and extend their lifespan. But do these supplements […]
Strongest NMN Supplement Launches: Longevity Breakthrough
The anti-aging and longevity supplement market has just witnessed a significant development with the launch of what’s being touted as the strongest nmn supplement currently available. According to recent announcements, Leading Edge has introduced a high-potency nicotinamide mononucleotide (NMN) formula that pushes the boundaries of NAD+ supplementation—a topic that has garnered substantial attention within the […]
Peptides for Performance: California Clinic’s Hot Take
The intersection of emerging sports trends and cutting-edge biohacking continues to evolve, as evidenced by a recent report from PR Underground highlighting the explosive growth of pickleball in Texas alongside California Trim Clinic’s endorsement of peptides for athletic performance enhancement. This development underscores a growing mainstream acceptance of peptide therapy—a topic that Tony Huge has […]
Rapamycin for Longevity: New Study Rivals Calorie Restriction
The quest for extended healthspan and lifespan has taken a significant leap forward with groundbreaking new research on rapamycin, a compound that has captured the attention of biohackers, longevity researchers, and performance optimization enthusiasts worldwide. According to recent findings published by Medical Xpress, rapamycin demonstrates life-extension properties comparable to caloric restriction—long considered the gold standard […]
My Pattaya Morning Stack: How I Run a Supplement Empire from Thailand at 39
People ask me what my morning looks like more than they ask about any single compound. They want the routine. They think there’s a secret hiding in the routine. Most days there isn’t a secret. There’s just a system, run on time, every day, while everyone else is still negotiating with their alarm clock. Here […]