Rapamycin + Metformin: The Anti-Aging Stack I’m Running at 53
Tony Huge’s actual rapamycin + metformin longevity protocol — dosing, scheduling, bloodwork markers, risks, why he runs it at 53.
Klotho: The Anti-Aging Protein the Supplement Industry Ignores
Klotho is the longevity protein with some of the strongest data in anti-aging — but nobody is selling it. Here is what raises it and why it matters.
NAD+ Injection vs Oral NMN: What Actually Reaches Your Tissues
Oral NMN and NR sound great in marketing. Here is what the bioavailability data actually shows, and why injectable NAD+ wins on dollars and effect.
Rapamycin Protocol: The mTOR Inhibitor I’ve Run for 18 Months at 5mg Weekly
Rapamycin is the only molecule with replicated lifespan extension in every mammal tested. Tony’s 18-month protocol — 5 mg weekly, food rules, bloodwork, and what most longevity influencers get wrong.
Eli Lilly Quintuple Agonist: Five Receptors, Greater Weight Loss Than Retatrutide
Eli Lilly is presenting animal data at ADA 2026 on a long-acting quintuple agonist that hits five receptors — GLP-1, GIP, glucagon, amylin, and calcitonin — and outperforms retatrutide in obese rats. Tony Huge breaks down the biochemistry, why it matters, and how it stacks with old-school rapid fat loss protocols.