Obicetrapib: The CETP Inhibitor That Came Back
Obicetrapib: The CETP Inhibitor That Came Back From the Dead Quick Summary Obicetrapib is an investigational once-daily oral CETP inhibitor, not approved for general prescription anywhere. Regulatory decisions in Europe, the UK and Switzerland were expected in the second half of 2026; there is no US approval. The CETP class was written off twice. Torcetrapib […]
Zoledronic Acid: Bone Density and the Geroprotector Case
Zoledronic Acid: Bone Density, and the Case For and Against It as a Geroprotector Quick Summary A nitrogen-containing bisphosphonate given as an IV infusion by a clinician. It inhibits farnesyl pyrophosphate synthase in osteoclasts, shutting down bone resorption long after a single dose. The fracture data are strong: in HORIZON-PFT, three annual infusions cut vertebral […]
Canakinumab and CANTOS: What Targeting IL-1B Achieved
Canakinumab and CANTOS: What Happened When Someone Finally Tested “Inflammaging” Head-On Quick Summary Canakinumab is a monoclonal antibody that neutralizes interleukin-1β (IL-1β), the cytokine released downstream of the NLRP3 inflammasome. It is FDA-approved for rare autoinflammatory conditions and gout flares — not for cardiovascular prevention or longevity. CANTOS randomized 10,061 post-heart-attack patients with hsCRP ≥2 […]
Low-Dose Colchicine for Heart Risk: What Trials Show
Low-Dose Colchicine for Heart Risk: What Trials Show Quick Summary June 2023: the FDA approved colchicine 0.5 mg (Lodoco) to reduce risk of MI, stroke, coronary revascularization and cardiovascular death in adults with atherosclerotic disease or multiple risk factors — the first anti-inflammatory approved for that purpose. LoDoCo2 (5,522 chronic coronary disease patients): primary composite […]
Boulder Biohacking Boom: Tony Huge’s Influence Expands
The wellness capital of America is experiencing a transformation that advocates like Tony Huge have been predicting for years. According to recent reports from Axios, Boulder, Colorado’s already-thriving wellness scene is receiving what industry insiders are calling a “biohacking boost” — a shift that aligns perfectly with the enhancement protocols and optimization strategies that Tony […]
Calocurb Research: Muscle Preservation During Weight Loss
The bodybuilding and biohacking communities have long grappled with one of the most challenging aspects of physique optimization: how to lose body fat while preserving hard-earned muscle mass. Recent research emerging from studies on Calocurb, a natural supplement derived from hops flower extract, suggests a potential solution to this age-old dilemma. According to a report […]
BPC-157: The Body Protection Compound Protocol for Tendon and Gut Repair
BPC-157 is a synthetic pentadecapeptide that drives angiogenesis at injury sites via VEGFR2 upregulation. Real protocol, real dosing, real results from Tony Huge.
Dubai’s First Biohacking Residences: Wellness Real Estate
The biohacking movement has evolved beyond supplements, peptides, and personal optimization protocols—it’s now reshaping the very spaces where people live. Dubai is set to unveil its first wellness-focused residential project with integrated biohacking amenities, signaling a major shift in how health optimization enthusiasts approach their living environments. According to MEP Middle East, Treppan Serenique Residences […]
Ozempic Muscle Wasting: What Bodybuilders Need to Know
The bodybuilding and biohacking communities have long been skeptical of mainstream weight loss drugs, and now science is validating those concerns. According to recent research reported by the Daily Mail, scientists have confirmed that GLP-1 receptor agonists like Ozempic trigger significant muscle wasting, making the phenomenon known as “Ozempic face” a documented medical reality rather […]
Peptide Regulation Update: What the Future Holds in 2026
The bodybuilding and biohacking communities are on the edge of their seats as the regulatory landscape for peptides in the United States approaches a critical turning point. According to a recent CNN report, clarity on the future of peptides in the US is imminent, potentially reshaping how millions of health optimization enthusiasts access these powerful […]