The Advanced Natty Plus Stack: Peptides, Secretagogues, and SERMs Combined

Once you have exhausted the benefits of the beginner stack and want to push further without crossing into suppressive territory, the advanced natty plus stack introduces compounds that directly manipulate hormonal signaling. This is where the natty plus approach separates itself from basic supplementation and enters the realm of genuine pharmacological optimization. After refining this stack across many client protocols over the years, here is the configuration that consistently delivers the best results.

The Core Three

The advanced stack is built around three core compounds: enclomiphene for testosterone, MK-677 for growth hormone, and a comprehensive micronutrient foundation. Enclomiphene at 6.25 to 12.5mg daily drives testosterone production upward by blocking estrogen feedback at the hypothalamus. MK-677 at 10 to 15mg before bed amplifies growth hormone pulses during sleep. Together, they elevate both major anabolic hormones while maintaining your endogenous production systems. This synergistic elevation is a direct application of the Tony Huge Laws of Biochemistry Physics, where modulating feedback inhibition (enclomiphene) and secretagogue pathways (MK-677) creates a multiplicative effect on anabolic output without system shutdown.

The micronutrient foundation, which should already be established from the beginner protocol, includes vitamin D at 5000 IU, zinc at 30mg, magnesium glycinate at 400mg, and boron at 10mg daily. These are not optional additions. They are the substrate that the core compounds need to function optimally.

Supporting Compounds

Tongkat ali at 400mg daily reduces SHBG and supports the cortisol-to-testosterone ratio, maximizing the free testosterone yield from enclomiphene’s production boost. Ashwagandha KSM-66 at 600mg daily manages cortisol, which otherwise antagonizes testosterone production.

DIM at 200mg daily provides gentle estrogen metabolism management, shifting estrogen toward less potent metabolites without the risks of pharmaceutical aromatase inhibitors. This becomes more important in the advanced stack because enclomiphene raises both testosterone and estrogen.

Berberine at 500mg twice daily manages the blood sugar impact of MK-677 and supports insulin sensitivity, which indirectly helps reduce SHBG. It also provides cardiovascular protection through lipid profile improvements. For a deeper dive into metabolic optimization, see the full Insulin Sensitivity Stack protocol.

Optional Peptide Addition

For clients willing to use injectable peptides, adding BPC-157 at 250mcg daily provides tissue healing and GI support that enhances nutrient absorption and recovery. Adding ipamorelin at 200mcg before bed alongside MK-677 creates additive GH elevation through complementary receptor pathways. These are optional because not everyone is comfortable with injections, and the core oral stack produces impressive results on its own.

What This Stack Achieves

Clients on the full advanced stack typically show total testosterone of 900 to 1200, IGF-1 elevated 50 to 80 percent above baseline, free testosterone optimized through SHBG management, cortisol reduced 20 to 30 percent from baseline, and improved sleep architecture from MK-677 with enhanced recovery rates.

These numbers approach what low-dose TRT plus GH peptides deliver, but with a critical difference: every endogenous system remains fully operational. LH and FSH are active. Natural GH pulsatility is maintained. Fertility is preserved. The off-ramp is straightforward because your body never stopped doing its own work.

Cycling the Advanced Stack

I recommend cycling the core compounds eight weeks on, four weeks off, while maintaining the micronutrient foundation continuously. During the off period, natural testosterone and GH levels decline toward baseline, but the recovery is smooth because there is no HPTA suppression to recover from. The off period also provides metabolic rest from MK-677’s blood sugar effects and receptor resensitization for enclomiphene.

Interesting Perspectives

While this stack is designed for hormonal elevation, its components have drawn interest for broader applications. The combination of a SERM (enclomiphene) with a ghrelin mimetic (MK-677) is being explored in niche longevity circles for its potential to counteract age-related declines in both the gonadal and somatotropic axes simultaneously, a concept sometimes called “endocrine system rejuvenation.” Furthermore, the inclusion of berberine and DIM creates a unique metabolic and estrogenic environment that may offer protective benefits against certain metabolic syndrome markers exacerbated by modern diets, turning a performance stack into a potential preventative health tool. The use of ashwagandha for cortisol management alongside these powerful compounds highlights a growing philosophy in biohacking: using adaptogens to provide system stability and buffer against the stress of potent pharmacological interventions.