DIM vs Calcium D-Glucarate: Estrogen Control | Tony Huge
DIM shifts estrogen metabolites via 2-hydroxylation while calcium D-glucarate blocks beta-glucuronidase reabsorption. Which is better and when to use both.
Niclosamide: The Antiparasitic Drug With Shocking Longevity Potential
Niclosamide inhibits mTOR, activates AMPK and autophagy, and kills senescent cells. The FDA-approved antiparasitic with remarkable anti-aging potential.
D-Ribose: Refuel Your ATP Energy Engine
Quick Summary – D-Ribose ATP Energy Protocol What: Five-carbon sugar that directly fuels ATP resynthesis via the pentose phosphate pathway and nucleotide salvage routes How Much: 5-10g daily for energy optimization; 15-20g daily post-intense training for accelerated ATP recovery (split into 2-3 doses) When: Post-workout within 1-2 hours for maximum ATP substrate availability; mornings for […]
Phosphatidylserine: The Cortisol Killer for Recovery and Performance
Phosphatidylserine at 400-800mg blunts cortisol response by 20-30%, accelerating recovery and protecting muscle. Complete protocol and stacking guide.
Irisin: The Exercise Hormone That Burns Fat While You Rest
Irisin converts white fat to calorie-burning brown fat through FNDC5 cleavage. Protocol to maximize irisin production through training, cold exposure, and compounds.
Boron: The Forgotten Mineral That Frees Your Testosterone
Quick Summary Boron is a trace mineral that significantly reduces SHBG (sex hormone-binding globulin), freeing bound testosterone into its bioavailable form Just 10mg/day for one week has been shown to increase free testosterone by 28% and reduce estradiol by 39% in clinical studies Works as a governor-remover per Law 1 of the tony huge laws […]
Low-Dose Naltrexone (LDN): The Immune System Optimizer Nobody Talks About
Quick Summary Low-dose naltrexone (LDN) is an off-label use of the opioid antagonist naltrexone at 1.5–4.5mg doses — roughly 1/10th the standard dose Works by briefly blocking opioid receptors, triggering a rebound upregulation of endorphins and enkephalins that modulates immune function Used by biohackers for autoimmune conditions, chronic inflammation, neurodegeneration, and even as an adjunct […]
Glucosamine: The Joint Supplement That’s Actually a Longevity Drug
Glucosamine is marketed as a joint supplement—a massive misunderstanding. It’s actually a longevity drug that activates sirtuins, suppresses mTOR, and extends lifespan by 15-20% in mice models. At 2-3g daily, you get autophagy, reduced inflammation, and improved glucose control. The joint health is the side effect.
Huperzine A: The Acetylcholinesterase Inhibitor That Sharpens Every Synapse
Quick Summary – Huperzine A: The Acetylcholine Amplifier Alkaloid from Chinese club moss – the most potent natural acetylcholinesterase inhibitor Dual mechanism: AChE inhibition (blocks acetylcholine breakdown) + neuroprotection Dosing: 50-200mcg daily (competitive protocol: 50-100mcg 2x daily) Effects: 25-40% improvement in memory consolidation, enhanced learning, sharper focus Works synergistically with Alpha-GPC for exponential cognitive amplification […]
ITPP: The Oxygen Enhancement Molecule That Outperforms EPO
Quick Summary — ITPP: The Oxygen Revolution Myo-inositol trisphosphate: shifts hemoglobin oxygen release curves rightward, delivering more O2 to working muscles Outperforms EPO without the cardiovascular risk — enhances 2,3-DPG without erythrocytosis Dosing: 400-600mg weekly (50mg daily optimization), 8-12 week cycles Effects: 8-15% VO2 increase, 10-20% endurance capacity gains, faster lactate clearance Mechanism: Direct allosteric […]