Ibogaine Legalized: RFK Jr., Joe Rogan, and the Pioneer Who Paid the Price
April 18, 2026: Trump signs an executive order accelerating ibogaine’s FDA review with RFK Jr. and Joe Rogan in the room. Meanwhile Guru Ameen Alai — the pioneer who popularized ibogaine’s anti-addiction thesis — serves 48 months in federal prison. The biochemistry, the protocol, and the pioneer paradox. Plus how to support via FreeAmeen.org.
SR-9009 (Stenabolic): The Rev-Erbα Endurance Compound
Quick Summary What: SR-9009 (Stenabolic) is a synthetic Rev-Erbα agonist that reprograms circadian metabolic gene expression toward enhanced oxidative capacity. Mechanism: Activates Rev-Erbα, which suppresses BMAL1 and triggers downstream mitochondrial biogenesis, fatty acid oxidation, and glucose disposal. Who it’s for: Endurance athletes, Enhanced Men doing cardio work, and anyone exploring exercise-mimetic pharmacology. Differentiator: Short half-life […]
DIM vs Calcium D-Glucarate: Estrogen Control | Tony Huge
DIM shifts estrogen metabolites via 2-hydroxylation while calcium D-glucarate blocks beta-glucuronidase reabsorption. Which is better and when to use both.
DIM vs Calcium D-Glucarate: Estrogen Control | Tony Huge
DIM shifts estrogen metabolites via 2-hydroxylation while calcium D-glucarate blocks beta-glucuronidase reabsorption. Which is better and when to use both.
SAMe: The Master Methylation Molecule for Mood, Liver, and Joints
Quick Summary – SAMe Methylation Protocol What: S-adenosylmethionine (SAMe) is the universal methyl donor in cellular metabolism, driving 200+ methylation reactions essential for neurotransmitter synthesis, liver detoxification, and connective tissue repair How Much: 400-800mg daily for mood and joint support; 1200-1600mg daily in divided doses for aggressive liver detoxification or depression protocols When: Morning on […]
Low-Dose Naltrexone (LDN): The Immune System Optimizer Nobody Talks About
Quick Summary Low-dose naltrexone (LDN) is an off-label use of the opioid antagonist naltrexone at 1.5–4.5mg doses — roughly 1/10th the standard dose Works by briefly blocking opioid receptors, triggering a rebound upregulation of endorphins and enkephalins that modulates immune function Used by biohackers for autoimmune conditions, chronic inflammation, neurodegeneration, and even as an adjunct […]
ITPP: The Oxygen Enhancement Molecule That Outperforms EPO
Quick Summary — ITPP: The Oxygen Revolution Myo-inositol trisphosphate: shifts hemoglobin oxygen release curves rightward, delivering more O2 to working muscles Outperforms EPO without the cardiovascular risk — enhances 2,3-DPG without erythrocytosis Dosing: 400-600mg weekly (50mg daily optimization), 8-12 week cycles Effects: 8-15% VO2 increase, 10-20% endurance capacity gains, faster lactate clearance Mechanism: Direct allosteric […]
Semaglutide Microdosing for Bodybuilders: The Smart Protocol
Quick Summary Semaglutide microdosing (0.25-0.5mg/week) gives bodybuilders GLP-1’s appetite control and insulin sensitization WITHOUT the muscle-wasting doses used for obesity At microdoses, semaglutide improves insulin sensitivity and nutrient partitioning while preserving the appetite needed for bulking phases The muscle loss associated with glp-1 drugs occurs at therapeutic obesity doses (1.7-2.4mg/week) — not at microdoses combined […]
C15:0 (Pentadecanoic Acid): The New Essential Fatty Acid
Quick Summary C15:0 (pentadecanoic acid) is an odd-chain saturated fatty acid recently proposed as the first newly identified essential fatty acid in 90 years Strengthens cell membranes by integrating into phospholipid bilayers, improving cellular resilience against lipid peroxidation Activates AMPK and PPAR-alpha/delta receptors while inhibiting mTOR — mimicking caloric restriction at the cellular level Found […]
Phenylpiracetam: Russia’s Banned Olympic Nootropic
Quick Summary Phenylpiracetam (Phenotropil/Carphedon) is a phenyl-modified piracetam derivative developed by the russian Academy of Sciences for cosmonauts Banned by WADA since 2004 due to significant psychostimulant and cold-resistance properties — one of the few nootropics on the prohibited list Mechanism: modulates NMDA, nicotinic acetylcholine, and dopamine D1/D2/D3 receptors simultaneously — true multi-receptor nootropic 10-60x […]